REMEDESIVIR for the Treatment of Covid-19

Feb 15, 2022

Remdesivir to treat covid-19

Remedesivir is an antiviral drug that blocks the formation of viral RNA and acts directly. It is indicated for the treatment of COVID-19 in adults and children under 12 years of age with acute/acute respiratory syndrome who do or do not require hospitalization and who have mild to moderate COVID-19.

The products in Remedesivir are:   Remdesivir Injection, 5 mg/mL, is a sterile, preservative-free, transparent, colorless to yellow, water-based solution that is diluted to 0.9% saline prior to administration by intravenous infusion. Remdesivir for Injection, 100 mg, is supplied in a clear glass vial as a single dose. Each vial contains sufficient volume to allow for withdrawal of 20 mL of a 5 mg/mL solution containing 100 mg of remdesivir. The appearance of the lyophilized powder is white to yellowish white to yellow. The inactive ingredients are the sulfobutylether-β-cyclodextrin (SBECD) sodium salt (3 g); Water for Injection, USP, and may include hydrochloric acid and/or sodium hydroxide to adjust pH.

How should remdesivir be stored before use?

Store remdesivir lyophilized powder for injection, 100 mg, vials below 30°C (below 86°F) until required. The lyophilized powder must be diluted before use. Injection Solution Store 5 mg/mL, refrigerated vials at refrigerated (2°C to 8°C [36°F to 46°F]) until required use. Before dilution, equilibrate the remdesivir injection at room temperature (20°C to 25°C [68°F to 77°F]). Airtight vials may be stored for up to 12 hours at room temperature before dilution. The concentrated solution must be diluted before use and should never be used after the expiration date.

Can any part of unused remdesivir be reused?

Remdesivir lyophilized powder, solution for injection, or diluted solution for infusion should not be reused or saved for future use. It is important to keep adequate records showing receipt, use and disposal of remdesivir. For unused intact vials, adequate records should be kept showing remdesivir disposal.

Is Remdesivir compatible with other intravenous drugs?

It is best not to take these medicines with other medicines as they may cause risks when taken together and may have harmful and harmful effects, so it is always best to consult your healthcare professionals for more information.

What other diluents can be used for dilution?

Remdesivir should not be administered simultaneously with any other drug. Other than 0.9% of saline, the compatibility of remdesivir injection with intravenous solutions and medications is unknown. Remdesivir injection (5 mg/mL solution) should be diluted in 0.9% sterile saline water.

Am I required to report adverse events to remdesivir?

All medication errors and serious adverse events or deaths that occur during remdesivir therapy potentially attributable to remdesivir are reported by the FDA by healthcare professionals and are reported within 7 calendar days of beginning the event.

Export Remedesivir

Remdesivir has now been removed from the Restricted category, after which the export of additional injections against prior authorization will not require a separate permission. India faced massive shortages during Covid-19, after which the export of this drug was banned. On June 14, 2021, the export ban was lifted and an export license agreement was issued for these goods. Since then, Remedesivir has been prescribed as a drug to treat Covid-19 in many countries.